Our investigation found that miR-146b-5p inhibited the expression of SEMA3 expression and affected EMT in ccRCC, and it has been reported that EMT is associated with the Notch and TGF-β signaling pathways [18], so we added contents related to the Notch and TGF-β signaling in our study. Here, TGFB1 is linked to nonpapillary renal cell carcinoma.