qRT-PCR and western blot unraveled that knocking down miR-146b-5p elevated the expression of EMT marker protein E-cadherin but reduced the expression of Notch1, Snail1, Snail2, N-cadherin and Vimentin in ccRCC cells, suggesting that EMT process of ccRCC cells was hindered. The gene discussed is CDH1; the disease is nonpapillary renal cell carcinoma.