According to the results of bioinformatics analysis as well as the cell experiments in the current study, SEMA3G was downregulated in ccRCC cells, which agreed with Li et al. Rescue assay has illustrated that miR-146b-5p accelerated ccRCC cell migration, invasion and EMT by inhibiting SEMA3G expression. This evidence concerns the gene SEMA3G and nonpapillary renal cell carcinoma.