IFNA1 and cancer: In immune cells, IFN-I response can act as an effector system that contributes to eliminating cancer cells via T cell priming and effector cytokine production [54, 55].The selection of cancer cells in a growing tumor likely involves acquirement of mechanisms that downregulate anti-tumor immunity, including IFN signaling but how cancer cells turn off IFN-I response in the tumors remains incompletely understood.