Interestingly tumours from patients F and H (NF2 mutation not detected) share a similar pattern of CNAs, including a combination of loss and high gain on chromosome 17q, with patient F showing an four-fold coverage increase in focal CNAs including RNF43 and RAD51C. NF2-positive patients have a genome-wide increase of gene copy-number alteration (p = 1.8E-14). Here, RNF43 is linked to neoplasm.