We further assessed the expression and prognosis of the predicted miRNAs in PAAD using starBase databases and found that only hsa-miR-16-5p (the upstream miRNA of CASP6 and CASP8) (Fig. 6B, P < 0.001) and hsa-miR-26a-5p (the upstream miRNA of PYCARD) (Fig. 6C, P = 0.025) were correlated with poor OS in PAAD patients (Fig. 6B, P = 0.041, Fig. 6C, P = 0.025). The gene discussed is CASP6; the disease is pancreatic adenocarcinoma.