We then screened 10 PRGs with prognostic value, namely, AIM2, CASP3, CASP4, CASP5, CASP6, CASP8, GSDMC, IL18, NLRP2, and PYCARD, which were negatively associated with prognosis in patients with PAAD. The gene discussed is CASP4; the disease is pancreatic adenocarcinoma.