Inhibition of COX-2, an inducible enzyme that is predominantly expressed during inflammation and is elevated after gastric injury brought on by NSAIDS or other stimuli, is believed to lower the chance of developing ulcers (Jackson et al. 2000; Buttgereit et al. 2001; Fornai et al. 2011; Magierowska et al 2018b; Magierowski et al. 2018). The gene discussed is PTGS2; the disease is ulcer disease.