Next, we used human fibroblasts derived from a patient with ataxia-telangiectasia-like disorder (ATLD2; kindly provided by Y. Shiloh from Tel Aviv University) that carry hypomorphic mutations in mre-1152 and hence cannot assemble an active MRN complex in response to DNA damage. This evidence concerns the gene PCNA and ataxia-telangiectasia-like disorder.