Computational analysis of HB and HCC patient transcriptomic profiles and our RNR-manipulated HB cells revealed distinct cellular network associated with these two RNR M2 subunits, that PTWAYRRM2 involves primarily in cell proliferation and DNA repair while PTWAYRRM2B participates heavily in stress and inflammatory responses. This evidence concerns the gene NR2E3 and hepatocellular carcinoma.