Potential target candidate diseases for the application of ISM-FISH other than MM include B cell lymphomas consisting of various subtypes, including double/triple hit lymphoma, defined by specific and/or prognostically important IGH chromosomal translocations, such as those involving BCL2, MYC, BCL6, or CCND1, or acute leukemias with subtype-specific chromosomal translocations involving core binding factors or Philadelphia chromosome [31–34]. The gene discussed is BCL2; the disease is acute leukemia.