RPS2 and viral infectious disease: Similar to the observation in herpes virus (a retrovirus)-infected cells [56, 57], ribosomal proteins (RPs) mRNA facilitate viral propagation were upregulated in BTBR/R mice, including Rpl29, the molecular signature of viral infection [58]; Rps3a1 and Rps2, which interact with viral IRES [59] (Fig. 3e, f); Eif3j, which is required for the assembly of the translation pre-initiation complex (PIC) at IRES to facilitate viral gene expression [60].