Possible scenarios of repurposing VPF as an anticancer agent are thus emphasized by its potent tumor-selective effects as well as its therapeutic versatility considering its administration (local or systemic), action (light-dependent or light-independent), molecular mechanisms mediating its oncosuppressive effects (YAP-dependent or independent, oxidative stress, proteotoxicity), as well as its sensitizing and synergistic potential15,26,27,37–42,46,51,57,58. Here, YAP1 is linked to neoplasm.