We used YAP/TAZ GI-ME-N KO lines, as well as the BE(2)-M17 and IMR-32 cell lines—noradrenergic and predominantly YAP negative NB models, and demonstrated that even in the absence of YAP/TAZ expression VPF continues to be a potent NB targeting agent, causing significant cell-death effects (see Fig. 5; Supp. The gene discussed is YAP1; the disease is neuroblastoma.