The VPF-induced NB antitumor effects identified in our study, including downregulation of oncogenic factors (YAP, TAZ, C-MYC, N-MYC, STAT3), formation of COX IV, GM130, STAT3 HMW complexes, disruption of cellular homeostasis, activation of cell stress and cell death effectors are presented in a summative schematic (Fig. 7). The gene discussed is COX4I1; the disease is neuroblastoma.