Recent studies have described the contribution of the Hippo tumor suppressor pathway downstream effectors YAP (Yes-associated protein) and its paralog TAZ (transcriptional co-activator with PDZ-binding motif; WWTR1) in NB tumorigenesis, treatment resistance and relapse, highlighting the functional relevance of targeting YAP/TAZ in NB tumors13–22. This evidence concerns the gene WWTR1 and neoplasm.