S.M 50%EE treated HepG2 and Caco-2 cell lines significantly downregulated VEGF expression level by more than four folds in HepG2 cancer cell lines and by three folds in Caco-2 cancer cell lines (0.29 ± 0.008 for HepG2 and 0.36 ± 0.019 for Caco-2, respectively). Here, VEGFA is linked to cancer.