S.M 50% EE treated HepG2 and Caco-2 cell lines significantly downregulated BCL2 expression level by more than ten folds in HepG2 cancer cells and by five folds in Caco-2 cancer cells (0.12 ± 0.001 for HepG2 and 0.28 ± 0.02 for Caco-2, respectively). This evidence concerns the gene BCL2 and cancer.