These phenolic acids act by activating JNK and p38-MAPK pathway, stimulating the cell death in cancer; also they show anti-proliferative and antiapoptotic effect via decreasing BCL2 expression, activating the Fas/FasL pathway, upregulating caspase-3, Bax, suppressing MMP-2 and VEGF dependent Akt/MMP2, and subsequently reducing cancer cells ability to survive, proliferate, and invade27,28. This evidence concerns the gene MAPK8 and cancer.