VEGFA and cancer: It has been shown that S.M 50% EE treated HepG2 and Caco-2 cancer cells significantly increases the number of total apoptotic cells with increase of p53 gene expression and downregulation of BCL2, Cyclin D, MMP9 and VEGF signaling pathway by more than fivefold followed by S.M aq, T.S aq and S.M 100% EE with a moderate apoptotic activity (from two folds up to five fold).