The presence of catechin in S.M 50% EE rather than S.M 100% EE, gives advantage to S.M 50% EE to be more effective than S.M 100% EE as Catechins plays a role in either cancer therapy or cancer prevention in vivo and in vitro via the inhibition of c-Jun and ERK1/2 phosphorylation and the suppression of VEGF-dependent angiogenesis26. This evidence concerns the gene MAPK3 and cancer.