CCND1 and cancer: S.M 50%EE treated HepG2 and Caco-2 cell lines significantly downregulated Cyclin D1 expression level by more than five folds in HepG2 cancer cells and by three folds in Caco-2 cancer cells (0.22 ± 0.0008 for HepG2 and 0.32 ± 0.018 for Caco-2, respectively).