Hepatocellular carcinoma has been linked to genomic instability, such as chromosomal or single nucleotide polymorphism, recurrent somatic mutations in genes such as the TERT promoter, p53, CTNNB1, ARID1A, and FGF as well as signaling pathways such as JAK/STAT, WntB-catenin, and PI3K-AKT-mTOR. Here, TP53 is linked to hepatocellular carcinoma.