SMARCA1 and neuroblastoma: Taken together, these observations, together with the previously established role of SWI/SNF chromatin remodeling in maintenance of lineage-specific25, we hypothesize that SOX11 allows NB cells to benefit from enhanced SWI/SNF activity and chromatin remodeling to sustain the establishment and maintenance of the adrenergic core regulatory circuitry of these arrested immature transforming sympathoblasts during tumor initiation.