Notably, (1) SOX11 directly regulates 10 SWI/SNF core components and subunit encoding genes, including SMARCC1, SMARCA4 and ARID1A, (2) is identified as an early expressed transcription factor of the adrenergic CRC in adrenergic high-risk neuroblastoma and (3) impacts on the adrenergic or mesenchymal transcriptional cell identity but does not induce full phenotypic conversion. The gene discussed is SOX11; the disease is colorectal carcinoma.