To provide further physical evidence for looping and contact of the cell type-specific enhancers with the promoter of SOX11, we performed 4C-seq analysis for the SOX11 locus in CLB-GA, KELLY (adrenergic MNoA and MNA cell line respectively with multiple SOX11 downstream enhancers), SH-EP and SK-N-AS (mesenchymal) NB cell lines and observed looping in this highly active region between the downstream enhancer loci with the SOX11 promoter in the adrenergic cell lines CLB-GA and KELLY while this interaction was not detectable in the mesenchymal cell lines SH-EP and SK-N-AS (Supplementary Fig. 2d). This evidence concerns the gene SOX11 and neuroblastoma.