Taken together, these observations, together with the previously established role of SWI/SNF chromatin remodeling in maintenance of lineage-specific25, we hypothesize that SOX11 allows NB cells to benefit from enhanced SWI/SNF activity and chromatin remodeling to sustain the establishment and maintenance of the adrenergic core regulatory circuitry of these arrested immature transforming sympathoblasts during tumor initiation. Here, SMARCA1 is linked to neoplasm.