Within the 270 kb shortest region of overlap of the commonly gained large chromosome 2 p segment (31% of cases), we identified focal amplifications (three primary NB cases with log2 ratio >2) and high-level gains (two primary NB cases and one cell line with log2 ratio >0.5) encompassing the transcription factor SOX11 as the only protein coding gene (Fig. 1a). Here, SOX11 is linked to neuroblastoma.