Lineage restricted expression was evident from high mRNA expression levels in human fetal neuroblasts and in sympathetic neuronal lineages during early development as compared to normal cortex from the adrenal gland (Supplementary Fig. 1g) and temporal increase of SOX11 expression was also noted in mouse NB tumor models in early hyperplastic lesions and full-blown tumors as compared to normal adrenal gland (Supplementary Fig. 1h, i). The gene discussed is SOX11; the disease is neoplasm.