We further assessed the phenotypic effects of SOX11 knockdown in adrenergic NB cell lines, including two MYCN amplified cell lines (NGP and IMR-32) and two MYCN non-amplified cell lines with high MYC activity (SK-N-AS) or hTERT activation (CLB-GA), using RNA interference knockdown experiments (siRNAs and/or shRNAs) (Fig. 3a, b). The gene discussed is MYC; the disease is neuroblastoma.