APC and adenoma: Surprisingly, in the classical Apc loss-of-function model (VApcΔInt) that is driven by activation of canonical WNT signalling20, there was a trend towards prolonged survival (median survival of 419 vs. 355 days; p = 0.12) and reduced number of adenomas and carcinomas per animal upon aberrant SNAIL expression (Fig. 2a–e; p = 0.08 and 0.14, respectively).