E-cadherin mRNA levels were reduced in Pdx1-Cre;KrasG12D/+;SnailKI/+;Cdh1lox/+ animals, which showed dramatically shortened median survival (78 days) compared to Pdx1-Cre; KrasG12D/+;SnailKI/+ (166 days) mice (Fig. 4f, g) and a clear shift of the tumours towards an undifferentiated mesenchymal phenotype (Fig. 4h, i). The gene discussed is PDX1; the disease is neoplasm.