Concomitant transgenic expression of SNAIL and activation of oncogenic KRASG12D in the pancreas of Ptf1aCre/+;LSL-KrasG12D/+;LSL-R26Snail/+ mice (termed PKrasG12D/+;SnailKI/+) accelerated the formation of acinar to ductal metaplasia (ADM) and PDAC precursor lesions (pancreatic intraepithelial neoplasia (PanIN)), and substantially increased cancer development (Fig. 1a–h and Supplementary Fig. S1d–f). Here, SNAI1 is linked to cancer.