In line, PKrasG12D/+;SnailKI/+;Cdkn2alox/+ mice with loss of both, the p16Ink4a and the p19ARF tumour suppressor barriers, had dramatically reduced median survival (Fig. 6l), confirming our data obtained with the Trp53R172H mutant in vivo model (Fig. 6e, f). This evidence concerns the gene CDKN2A and neoplasm.