Several kinds of programmed cell death are reported to be involved in the development of diabetic cardiomyopathy, among them apoptosis are well-studied.8,9 Pyroptosis is a newly identified form of programmed cell death, which could induce cell lysis and the release of pro-inflammatory factors (such as IL-1β and IL-18) and high-mobility group box-1 protein (HMGB1).10 Recently, Shao et al.11 defined pyroptosis as gasdermin-induced necrotic cell death and applied this term to all gasdermin family members-induced cell death through membrane permeabilization. Here, HMGB1 is linked to diabetic cardiomyopathy.