Recent studies have reported that circRNAs could regulate diseases and that circRNAs can be considered as potential markers for the diagnosis of several diseases as well as therapeutic target genes.31 For example, circRNA HRCR is proposed to possess the ability to sponge miR-223 and is beneficial for cardiac hypertrophy and heart failure.32 In addition, circ-Foxo3 is found to be able to promote cardiac senescence.33 To date, few studies have been performed to test the role of circRNAs in DCM. This evidence concerns the gene FOXO3 and heart failure.