CALR and cancer: Calreticulin translocates to the cell membrane and serves as an “eat me” signal to promote efferocytosis of apoptotic cells, including damaged, aged, and malignant cells, and leads to the elimination of these cells.172 Calreticulin has been demonstrated to be the dominant pro-phagocytic signal in a myriad of human cancers and is counterbalanced by CD47.