Monoclonal antibodies against HLA-G have been successfully used against cancer as part of an immune checkpoint suppression strategy.368 Since the most important function of MHC-I is antigen presentation and since MHC-1 is ubiquitously expressed on all types of cells, targeting MHC-I enhances phagocytosis of tumor cells by macrophages but may also lead to the loss of T-cell recognition of antigens and tumor immune evasion. This evidence concerns the gene HLA-G and cancer.