In EGFR-mutant NSCLC, the augmented CD47 expression is closely related to the off-target resistance to the tyrosine kinase inhibitor (TKI) gefitinib.253 In glioblastoma multiforme (GBM), GBM cells with higher CD47 expression possess the characteristics of stem cells and have poor clinical results,254 and irradiation or temozolomide (TMZ) significantly enhances anti-CD47-mediated phagocytosis of GBM cells in vivo and in vitro. This evidence concerns the gene EGFR and glioblastoma.