The expression of SIRPα on DCs inhibits their phagocytosis,213 and blocking the CD47-SIRPα pathway activates DC cells to phagocytize tumor cells.214 CD47 inhibits the transformation of immature dendritic cells (iDCs) to mature cells in terms of both phenotype and function.213 CD47 also regulates DC migration to lymphatic organs. The gene discussed is CD47; the disease is neoplasm.