The basic function of MHC is to distinguish “self” and “non-self” and present the tumor-associated antigens (TAAs) to T cells to activate the adaptive immune response.68 Moreover, MHC-I on the surface of tumor cells binds to leukocyte immunoglobulin-like receptor subfamily B 1 (LILRB1) on the surface of macrophages to promote tumor cell escape from macrophage phagocytosis. This evidence concerns the gene HLA-C and neoplasm.