In an effort to confirm these DNA repair outcomes at different locus, we recruited a sperm donor homozygous for LDLRAP1 (g.24059 G > A, NG_008932.1) mutation located on chromosome 1 and associated with familial hypercholesterolemia (FH) (Supplementary Fig. 3a). Here, LDLRAP1 is linked to familial hyperaldosteronism.