We fertilized WT oocytes with sperm donated by a subject carrying a heterozygous mutation in exon 22 of MYH7 gene (1 bp C > T substitution; g.15819 C > T, NG_007884.1) located on chromosome 14, and implicated in familial hypertrophic cardiomyopathy (HCM) (Supplementary Fig. 3b). Here, MYH7 is linked to hypertrophic cardiomyopathy.