IL-8, IL-15, MCP-1, sICAM-1, sVCAM-1, sFlt-1, and VEGF-A have been previously described to be associated with cognitive decline and may be involved in BBB impairment.9,13,18 We found that the effects of WML on cognitive decline were independent of biomarker levels. The gene discussed is IL15; the disease is Mental deterioration.