GPT and Acute hepatitis: Evidence of acute hepatitis, clinically significant chronic hepatitis or evidence of clinically significant impaired hepatic function through clinical and laboratory evaluation (including alkaline phosphatase (ALP) > 1.5 × upper limit of normal (ULN); alanine transaminas (ALT) or aspartate transaminase (AST) > 2 × ULN; gamma-glutamyl transferase (GGT) > 3 × ULN)