Furthermore, ex vivo cytokine analysis demonstrated that DC2, not DC1, are the main source of the key proinflammatory cytokine IL-12p40/70 and IL-23p19 in response to sensing tumor-derived nucleic acids, the latter of which is a potent activator of IFN-γ production in NK cells (23). This evidence concerns the gene ZDHHC4 and neoplasm.