ADORA2A and major depressive disorder: On one hand, it has been establishedthat the blockade of A2AR prevents moods dysfunction uponrepeated stress,31−33 in accordance with the association of A2AR polymorphisms with the incidence of major depression.34 In parallel, there is robust evidence that P2X7R antagonism also prevents mood dysfunction upon repeatedstress,35−38 also in accordance with the association of P2X7R polymorphismswith the incidence of major depression (reviewed in ref (39)).