Despite an increasing overexpression trend of p16INK4A in the high‐grade lesion and invasive cancer conditions, there are no substantial gaps or nicks visible in the cell number versus p16INK4A‐signal intensity two‐dimensional curve, which might be used as a signature to divide abnormal/neoplastic cells from normal cells during FCM analysis21; conversely, for other histotypes of cells, such as leukaemia cells, these gaps can be easily observed and used to discriminate neoplastic cells from non‐neoplastic cells, thereby dividing them into two independent groups.19, 20. Here, CDKN2A is linked to cancer.