CDKN2A and cancer: However, although the p16INK4A mono‐ or p16INK4A/Ki‐67 dual‐immunostaining techniques have been widely applied by pathologists to recognise pre‐cancerous/cancerous lesions and have achieved significant success in cervical pathology,11, 12, 13, 14, 15, 16 detection tools for intimately monitoring p16 INK4A dysregulation events as well as for real‐time assessment of cervical pre‐cancer/cancer risks are not yet available.