Compared with the p16INK4A‐positive ratios detected in the HPV‐negative controls (13.9 ± 1.8%; Table S6), women infected with HPV‐16 (single infections) were associated with the highest p16INK4A increments (1.6%; Figure 3D and Table 2), while those infected with HPV‐18 or other high‐risk (HR) genotypes (single infections) exhibited relatively lower increments (0.5–1.4%; Figure 3D and Tables 2, also Table S3a). Here, CDKN2A is linked to infection.