As TRAF2 is required to interact with cIAP1 or cIAP2 to promote TNFR1‐induced NF‐κB signalling and suppress TNF‐induced cell death, inhibition of TRAF2 or cIAPs is necessary to sensitise tumour cells to TNF‐induced cell death. The gene discussed is NFKB1; the disease is neoplasm.