For example, E6AP, a member of other HECT family drives cervical cancer by associating with E6 protein of human papillomavirus to promote proteasome degradation of p5354, 55; the NEDD4 family members WWP1 and NEDD4 promote PI3K/AKT signalling by catalysing the ubiquitin‐mediated degradation of PTEN56; ITCH, another NEDD4 member, is an important regulator of immune response.57, 58. The gene discussed is NEDD4; the disease is cervical cancer.