To explore the involvement of monocyte-derived macrophages regulated by m6A during AD progression, we first showed that METTL3 did not alter the expression of surface cell markers (CD11b, F4/80) on macrophages from WT (Mettl3fl/flLyz2-/-) and KO (Mettl3fl/flLyz2Cre/-) mice (S1A Fig). This evidence concerns the gene ITGAM and Alzheimer disease.