We then tested whether perturbing the equilibrium state would allow for tumor outgrowth, as this was the key parameter initially used to define immune equilibrium in mice.3 Stable equilibrium using d106S-IL12 was established in a large cohort of mice, which were rerandomized at day 40 into new groups to receive either anti-CD4, anti-CD8, anti-IFNγ, anti-NK1.1, or isotype control depleting antibodies every 3 days while continuing to receive d106S-IL12. Here, CD4 is linked to neoplasm.