CASP8 and neoplasm: We therefore generated B16 Casp8 knockout cells, which lack caspase 8 (Figures S7B, S7E, and S7H), critical for extrinsic apoptosis, and we observed that caspase-8-deficient tumor cells were still able to be controlled by d106S-IL12 therapy to the same degree as wild-type cells (Figure 5D), suggesting that this cytotoxic pathway was not required.