HLA-C and neoplasm: Work from our lab has shown that in the context of cIAP1/2 antagonism, T cells can repolarize macrophages to phagocytose live tumor cells in a manner independent of direct T cell recognition of tumor MHC or IFNγ sensing by the tumor.62 Through scRNA-seq of the tumor microenvironment, we saw a strong IFNγ response generated by many cells, but most notably by macrophages.