Mice given combined therapy had more T cells infiltrating tumors compared with mice treated with either single-agent blockade of IL-6 (P = 0.035), CTLA-4 (P = 0.038), or isotype controls (P = 0.0001), indicating a superior effect of IL-6 and CTLA-4 blockade on T cell infiltration in this tumor model (Figure 1D). This evidence concerns the gene CTLA4 and neoplasm.