PDAC tumors were established in mice and then treated with either anti–IL-6 and/or anti–CTLA-4 Abs, as shown in scheme Figure 1A. For these studies, the MT5 cell line was used, which originated from a KPC tumor, harboring G12D-mutated (Kirsten rat sarcoma viral oncogene homologue) Kras and R172H-mutated Trp53 (12). Here, KRAS is linked to neoplasm.