We believe that the decreased expression of LINC00324 in LUAD increased the level of miR-200c-3p, which promoted the expression of TFAP2A, while LINC00324 may also regulate the expression of downstream TFAP2A through a mechanism of competitive binding with miR-200c-3p, thus affecting the biological behavior of tumor cells and providing new approaches and ideas for clinical targeting therapy and targeted drug development of LUAD. This evidence concerns the gene TFAP2A and neoplasm.