The stage [hazard ratio (HR): 1.589, 95% confidence interval (CI): 1.246–2.027, P < 0.001], diabetes (HR: 1.556, 95% CI: 1.068–2.267, P = 0.021), histologic grade (HR: 2.078, 95% CI: 1.289–3.352, P = 0.003), and TARS expression (HR: 4.912, 95% CI: 1.765–13.674, P = 0.002) showed independent prognostic value for overall survival of endometrial cancer. This evidence concerns the gene TARS1 and endometrial cancer.