The stage (HR: 2.109, 95% CI: 1.536–2.897, P < 0.001), histologic grade (HR: 2.646, 95% CI: 1.335–5.244, P = 0.005), and TARS expression (HR: 6.723, 95% CI: 1.606–28.152, P = 0.009) showed independent prognostic value for disease specific survival of endometrial cancer. The gene discussed is TARS1; the disease is endometrial cancer.