CYB5D2 and hepatocellular carcinoma: By lasso regression analysis and multivariate cox analyses in 79 prognostic DEGs, we identified 5 genes including three risk factors (CCDC112, TRNP1, CFL1) and two protective factors (CYB5D2, SLC22A1) and created a prognostic model in HCC according to these five genes (Supplementary Figure 5 and Supplementary Table 3).