In the present study, we focus on the SNP rs12212067. FOXO3 longevity-associated SNPs were associated with mitigation of the lifespan-shortening effect of having a cardiometabolic disease (CMD, i.e., one or more of the conditions coronary heart disease (CHD), hypertension, and type 2 diabetes) in late life [5]. This evidence concerns the gene FOXO3 and coronary artery disorder.