CETP and hyperinsulinemic hypoglycemia, familial, 4: Given the observation of elevated concentrations of HDL-C, a negative ASCVD risk factor, in patients with CETP deficiency [71, 108], and that in rabbits, CETP inhibition increases HDL concentrations and decreases ASCVD [109], several CETP inhibitors were developed and tested as an ASCVD therapeutic [92, 108–116].