Polygenic risk score (PRS), for instance, was associated with higher penetrance of PD in large cohorts of LRRK2-G2019S carriers [44, 45], and the combination of MDS Research Criteria for Prodromal PD with PRS has been proposed for LRRK2-NMC to identify subjects at higher risk [3]. Here, LRRK2 is linked to Parkinson disease.