LRRK2 and Parkinson disease: Similarly, two recent studies conducted on LRRK2-G2019S-PD from different geographical areas (Tunisia: 142 LRRK2-G2019S-PD, 200 sPD, 57 LRRK2-G2019S-NMC; Israel: 65 LRRK2-G2019S-PD, 100 sPD) showed an association between older PD age at onset and tobacco use and coffee and tea consumption [50, 51], suggesting a protective effect of these factors.