A retrospective case–control study found that regular use (defined as two or more pills per week for 6 months or more) of NSAIDs (both aspirin and ibuprofen) may lower the risk for PD with OR of 0.34 among LRRK2 variant carriers, including pathogenic (such as G2019S) and risk variants [47••]. Here, LRRK2 is linked to Parkinson disease.