RAI14 and neoplasm: The highly malignant and extensive lesions of advanced TNBC are responsible for a more pronounced tumor-killing effect of cytotoxic drugs at the beginning of treatment; simultaneously, since there may be a positive correlation between RAI14 levels and the severity of the disease, patients with high baseline RAI14 levels were inclined to had a more noticeable response to early treatment while RAI14 served a more effective role in chemotherapy monitoring.