CHI3L1 and ischemic stroke: Kjaergaard et al. measured plasma YKL-40 in 21647 individuals from the Danish general population, and found that high plasma YKL-40 was associated with risks of ischemic stroke with an adjusted HR of 1.99 (95% CI 1.49-2.67) per standard deviation (SD) of YKL-40 [7].