In the unadjusted model, when comparing with the first quartile of YKL-40, the third and fourth quartiles were independently associated with poor outcome (OR 3.874, 95% CI 2.365-6.348 for the third quartile; OR 8.345, 95% CI 5.154-13.511 for the fourth quartile) as well as all-cause mortality (HR 6.022, 95% CI 2.838-12.774 for the third quartile; HR 9.354, 95% CI 4.490-19.487 for the fourth quartile), and the fourth quartile was independently associated with recurrent stroke (HR 1.884, 95% CI 1.091-3.255). This evidence concerns the gene CHI3L1 and stroke disorder.