IRAK4 and hyperinsulinemic hypoglycemia, familial, 4: These two cohorts had similar age distributions (mean age of patients with MyD88 or IRAK-4 deficiency: 13.0 yr [IQR 6.5–16.0] vs. NC3 series: 11.9 yr [IQR 6–16.1]), but there were significantly more male patients in our cohort (84.2%) than in the NC3 cohort (50.1%; P = 0.006; OR 5.3, 95% confidence interval [CI] 1.5–18.1).