IRAK4 and COVID-19: We also searched for an enrichment in rare (gnomAD frequency <10−3) pLOF variants of IRAK4 and MYD88 in 3,269 patients with critical COVID-19, and 1,373 controls with asymptomatic or mild SARS-CoV-2 infection from the CHGE (Matuozzo et al., 2022).