RARA and leukemia: Linkage of PML to RARA generates a PML-RARA oncoprotein that acts as a transcription factor that deregulates transcriptional programs blocking the differentiation of hematopoietic progenitor cells and thus causing leukemia (Grignani et al., 1993; Kwok et al., 2006; Martens et al., 2010; Mikesch et al., 2010; Tan et al., 2021).