When divided into quartiles of expression, ascending N-cadherin protein expression, but not CDH2 mRNA levels, showed a significant, inverse decrease in the frequency of patients presenting a new neoplasm following initial therapy (protein, P = 0.0074; mRNA, not significant; Fig. 9 I), whether patients were with or without tumor (protein, P = 0.0228; mRNA, not significant; Fig. 9 J), and lymph node metastasis positivity (protein, P = 0.0213; mRNA, not significant; Fig. 9 K). Here, CDH2 is linked to metastatic malignant neoplasm in the lymph nodes.