Consistent with this finding, human and mouse adipocyte-derived conditioned media increase BCC migration and proliferation by activating the PI3K-AKT-mTOR pathway and upregulating the expression of target genes, such as TNF-α, IL-1, and IL-6, suggesting that tumor-derived molecules regulate the TME in addition to the tumor, thereby aggravating diseases102. Here, TNF is linked to neoplasm.