Another study showed that ectopic IL-8 expression in tumor-adjacent adipocytes converted adipocytes into CAAs, with high levels of NF-κB and NF-κB targets (leptin/IL-8/IL-1 and an active pre-oncogenic STAT3-dependent EMT phenotype), on BCCs and in orthotopic tumor xenografts in mice. The gene discussed is NFKB1; the disease is neoplasm.