Using a zebrafish model of metastasis, Rodriguez et al.84 showed that IL-8 generated by breast adipocytes might synergize with LFA-1, integrin, CCL5, or CCL2 to transform the BC microenvironment into a pro-inflammatory and pro-angiogenic state, while inducing resistance against anti-VEGF treatment in ER-positive BCCs. The gene discussed is CCL2; the disease is breast cancer.