IL6 and obesity due to melanocortin 4 receptor deficiency: As demonstrated by Tiwari et al.53, obesity induces a pro-inflammatory metabolic activation phenotype in mammary adipose tissue macrophages in vivo, leading to the secretion of IL-6 in an NADPH oxidase 2-dependent manner and promotes stem-like features to alter the niche and support tumor formation via glycoprotein 130 signaling in TNBC cells.