Gonçalves et al.46 reported that an obesogenic diet augments proinflammatory mediators (CCL2, IL-6, COX-2, and PGE2) in breast tissue, along with the formation of crown-like structures of the breast (CLS-B) and upregulation of local aromatase and estrogen, which accelerate COX-2-dependent breast tumor formation. This evidence concerns the gene IL6 and breast neoplasm.