Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses showed downregulation of genes involved in cardiac muscle contraction and dilated cardiomyopathy in CM-Pcsk9−/− mice (see Supplementary material online, Figure S2A and B, Table S3); these results were confirmed by targeted RNA analysis (see Supplementary material online, Figure S2C and D). The gene discussed is PCSK9; the disease is dilated cardiomyopathy.