To determine the role of high‐level SULT1C2 expression in HCC progression, we decided to investigate further how the high‐level SULT1C2 expression impacted the biological functions of HepG2 and Huh7 cells because they expressed the highest SULT1C2 levels among the four cell lines examined. This evidence concerns the gene SULT1C2 and hepatocellular carcinoma.