Some common viral carcinogenic features of cancer development include (i) direct transformation through the expression of viral genes, (ii) encoding oncoproteins, (iii) inactivating regulators of genome stability, (iv) interference in cell viability and cell cycle, (v) inactivating p53 and retinoblastoma proteins (pRB), (vi) activation of the DNA damage response, and (vii) changes to cellular levels of reactive oxygen species (ROS) and induction of oxidative stress (OS) (Table 1) (Figure 1). The gene discussed is RB1; the disease is cancer.