CCNE1 and hepatocellular carcinoma: However, genome integration of HBV into hepatocytes increases the risk of HCC development, which occurs during chronic infection of HBV and leads to an increase in the expression level of cancerous genes, including telomerase reverse transcriptase (TERT), mixed‐lineage leukemia 4, and encoding cyclin E1 (CCNE1) (encoding cyclin E1).22, 23