YY1 acts as a TF to suppress some classical anti‐cancer pathways (e.g., p53 signaling axis and Fas/FasL‐mediated apoptosis) but promote the oncogenic pathways (e.g., c‐myc signaling axis and Wnt signaling axis).26, 27, 31, 32, 35. The gene discussed is YY1; the disease is cancer.