The expression of YY1/nuclear factor‐κ‐gene binding P65 (NF‐кB‐P65) complex indirectly regulated by Lnc‐TLCD2‐1 may negatively mediate the radio‐sensitivity of CRC cell lines by regulating tumor microenvironment infiltration of immune cells.41 This evidence concerns the gene YY1 and colorectal carcinoma.