One study showed that YY1 is responsible for the epigenetic silencing of DTDST and ST6GalNAc6 (functioning to maintain the synthesis of normal glycans) in early‐stage CRC by recruiting histone repressive complex, polycomb repressive complex 2 (PRC2) containing enhancer of zeste homolog 2 (EZH2) to their promoter regions. The gene discussed is YY1; the disease is colorectal carcinoma.