FOXP3 and neoplasm: Few studies have investigated theimpact of these cells in PCa, but one study indicates that T-bet+Th1-cells could reduce the metastasis rate and another suggests thatT-bet+ Th1-cells can enhance anti-tumor responses in hepatocellularcarcinoma.10,14 Increased infiltration of FOXP3+ Tregs was also seenafter all three treatments; this might reflect efforts by the tissue to reduce thepro-inflammatory reactions and mitigate the damage, which if occurring duringtherapy could contribute to a reduced effect of the treatments.20,23