It has previously beenshown that the majority of the TAM present in PCa tissue is of an M2phenotype.18,19,32 After neoadjuvant ADT combined with RT, a significant increasedinfiltration of CD68+ TAM was demonstrated using the mIHC method.Standard IHC staining showed that 75% of untreated biopsies and 92% of cases treatedwith neoadjuvant ADT combined with RT had a high infiltration of CD163+cells. This evidence concerns the gene CD163 and posterior cortical atrophy.