VEGFA and cancer: As possible therapeutic candidates for treatment of cancer, two major groups of G-quadruplex DNA structures have garnered attention: (A) They are capable of formation at the single-stranded guanine-overhang of telomeric DNA, and (B) those inside genomes, particularly within the promoter regions of specific oncogenes like c-MYC, VEGF, c-KIT, PDGF-A, k-RAS, Hsp90 and HIF1 etc [7].