Given that sleep disturbance leads to daytime increases in circulating levels of inflammatory cytokines and C-reactive protein (CRP) (Irwin, 2015, 2019; Redwine et al., 2003; Shearer et al., 2001; Vgontzas et al., 1999), that modest amounts of sleep loss activate cellular and inflammatory nuclear signaling pathways (e.g., nuclear factor [NF]-κB) (Irwin et al., 2006, 2008), and that treatment of insomnia promotes a reversal of systemic and cellular inflammation in older adults (Irwin et al., 2014, 2015b), abundant evidence supports the link between insomnia and inflammatory activation. The gene discussed is CRP; the disease is insomnia measurement.