CD8A and cancer: They focused on two CD8+ T cell populations: (i) the terminally exhausted CD8+ T cells, a homogeneous population defined by Ly108lowTIM-3hi and characterized by a specific irreversible epigenetic imprint (62,63) and (ii) the stem-like CD8+ T cells defined by Ly108hiTIM-3low with a distinct lineage from all other viral-specific CD8+ subtypes, and suggestive to be a crucial player against chronic infection and cancer (64–66).