MSN and early-onset autosomal dominant Alzheimer disease: ,57,58 As our co-expression analyses of human Alzheimer’s disease and tau transgenic mice indicated that Moesin involvement in tauopathy is not restricted to wild-type versus mutant tau, we analyzed Moesin in a Drosophila model of tauopathy that features panneuronal expression of a disease-associated mutant form of tau (tauR406W, referred to hereafter as “tau transgenic Drosophila” for simplicity)48 that features a moderate degree of neurotoxicity that is well suited for genetic analyses.