The modular structure of the human network, which involves deposition of human wild-type tau in brains of affected individuals, is well preserved in the network derived from tau transgenic mice despite transgenic overexpression of a disease-associated tau mutation in this model, indicating that the rTg4510 mouse model of tauopathy recapitulates changes that occur in sporadic human Alzheimer’s disease. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.