The modular structure of the human network, which involves deposition of human wild-type tau in brains of affected individuals, is well preserved in the network derived from tau transgenic mice despite transgenic overexpression of a disease-associated tau mutation in this model, indicating that the rTg4510 mouse model of tauopathy recapitulates changes that occur in sporadic human Alzheimer’s disease. This evidence concerns the gene MAPT and tauopathy.