Integrative analyses of fb-PMT down-regulated DEGs whose protein products are engaged in PPI with multiple TFs (TFs PPI) and/or with PPI Hub Proteins reveal the auto-regulatory PPI networks of TFs PPI and PPI Hub proteins that (1) regulate expression of DEGs down-regulated by fb-PMT treatment in human GBM cells, and (2) fb-PMT down-regulate expression of genes encoding the TFs PPI and PPI Hub Proteins constituting members of these PPI networks (Supplementary Figure S5). The gene discussed is ELAVL2; the disease is glioblastoma.