NPPB and heart failure: Furthermore, MS caused lipotoxicity-induced cardiotoxicity, resulting in the progression of heart failure, including abnormal cardiac function (increasing LVESd, IVSd, IVSs, PWTd, and PWTs), high expression of BNP, increased cardiac muscle fiber area and heart weight, and activated the mitochondria-regulated apoptotic pathway to promote cardiomyocyte apoptosis.