We observed a global decrease of plaque area in CA1 and CA3 in hippocampus of APP/PS1 mice 2 weeks after inducible miR-155 knock-out in microglia compared to age matched AD mice (Fig. 3C, D are representative images, quantification shown in 3 E; unpaired two-tailed t-test, p = 0.04797). The gene discussed is APP; the disease is Alzheimer disease.