Among them, 12 genes were upregulated in AML and associated with prognosis: MIR181A1HG, MIR222HG, KIT, HGF, MCTP2, FCHSD2, ERG, ITGA4, ITPR2, DPYD, CDK6, SPN, and ARHGEF6. The gene discussed is SPN; the disease is acute myeloid leukemia.