PCR analysis further demonstrated that the expression levels of ITGA4, ITPR2, ADGRE2, ANKRD28, KDM5B, and CDK6 in NK-AML (M4/M5) were significantly higher than those in normal controls, suggesting that these genes may be possible biomarkers of NK-AML. The gene discussed is ADGRE2; the disease is acute myeloid leukemia.