AKT1 and leukemia: Cluster 12 was comprehensively and highly involved in AML-related signaling pathways (the PI3K-Akt/Ras/MAPK/Phospholipase D signaling pathway), acute myeloid leukemia, hematopoietic cell lineage, and transcriptional misregulation in cancers, suggesting that the function of cluster 12 was highly correlated with AML compared to that of the other leukemia cell clusters (Fig. 3C–D).