GSEA revealed significant activation of gene sets associated with hematopoietic stem cells, hypoxia, NPM1 mutation-related AML, p53 signaling pathways, and FGFR and ERBB2 receptor tyrosine kinase family-mediated signaling pathways in cluster 12 (Fig. 5). The gene discussed is NTRK1; the disease is acute myeloid leukemia.